Epigewhoo? LOL
1- Epigenetics is the study of gene expression without the altering of genetic coding itself. For example, your DNA from your parents is inside you and your siblings, however each of you express the sequence differently with the color of your eyes, hair and skin. Make sense? If not, your on your own....ha
2- Telomeres are the ends of your DNA that have been proven scientifically that the longer they are the longer and healthier you will be!
3- The purpose of methylation is to control nearly every reaction inside your body including detoxification, neurotransmitter production, fatty acid metabolism, energy production, cellular repair, inflammation reduction and infection control. Poor methylation is linked in autoimmune disease and cancers.
4- NAD+ or nicotinamide adenine dinucleotide is a co-enzyme involved in virtually all energetic processes found inside your body - without which you’d die. NAD+ is responsible for converting food to energy, repairing DNA damage, strengthening the immune system, burning fat, and regulating the body’s circadian rhythm. Methylation is dependent on NAD+. Unfortunately, as we get older our NAD levels drop and this speeds up the aging process leading to disease.
Debby downer?
There is good news! You can boost your NAD+ levels naturally by exercising, ingesting niacin, feeling hungry, getting breathless, and depleting your glucose levels. Bottom line: stop eating anything that comes from a box bag or can! Eat a Mediterranean diet rich in fish, olive oil and green leafy veggies. Avoid sauces, marinades and glazes. Drink water and avoid alcohol like the plague people!
Of course supplements help too (thank goodness). I took Thorne 5-MTHF to improve my methylation after having Lyme to recover. I also continue to take Life Extension BioActive Complete B Complex. Additionally, I recommend taking Quicksilver Scientific Liposomal NAD+ Gold to boost those NAD+ levels.
Of course at the Med Spa at Clinical Edge we provide these intravenously as well! Stop in soon!
References
Blum, K., Han, D., Baron, D., Kazmi, S., Elman, I., Gomez, L. L., . . . Badgaiyan, R. D. (2022). Nicotinamide adenine dinucleotide (NAD+) and enkephalinase inhibition (IV1114589NAD) infusions significantly attenuate psychiatric burden sequalae in substance use disorder (SUD) in fifty cases. Current Psychiatry Research and Reviews, 18(2), 125-143. doi:10.2174/2666082218666220527114427
BRAIDY, N. (2018). Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans. Journal of Cellular Neuroscience and Oxidative Stress, 10(3), 779. doi:10.37212/jcnos.610084
Lozoya, O. A., Martinez-Reyes, I., Wang, T., Grenet, D., Bushel, P., Li, J., . . . Santos, J. H. (2018). Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation. PLoS Biology, 16(4), e2005707. doi:10.1371/journal.pbio.2005707
Nemirovich-Danchenko, N. M., & Khodanovich, M. Y. (2020). Telomerase gene editing in the neural stem cells in vivo as a possible new approach against brain aging. Russian Journal of Genetics, 56(4), 387-401. doi:10.1134/S1022795420040092
Sheldon, E. L., Ton, R., Boner, W., Monaghan, P., Raveh, S., Schrey, A. W., & Griffith, S. C. (2022). Associations between DNA methylation and telomere length during early life: Insight from wild zebra finches (taeniopygia guttata). Molecular Ecology, 31(23), 6261-6272. doi:10.1111/mec.16187
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